Fatty liver caused by drugs

  Fatty liver , also known as hepatic steatosis. It is a condition of fat accumulation in the liver> 5% by weight of the liver. Symptoms are often seen as hepatomegaly discreet, modest increase metabolic enzymes and alkaline phosphatase

Drug-induced fatty liver may occur with the following components:

1.TETRACYCLINE

Through the use of oral tetracycline can cause fatty infiltration form small vesicles, usually not to the clinical consequences. The presence and degree of steatosis is associated with dose. In some cases severe fatty infiltration, liver failure and death can occur when using intravenous tetracycline in women to treat urinary tract infections (107). The main mechanism of fatty liver is reduced by tetracycline decreased protein synthesis and secretion of VLDL in the liver.

2.VALPROIC ACID

Anticonvulsant valproic acid rarely cause fatty infiltration of the liver form small vesicles, usually associated with hepatic necrosis, especially in children, can lead to liver failure and death. Abnormalities in liver usually appear 2 to 4 months after initiation of drug use. The metabolites of valproic acid hypoglycin A similar, pentanoic acid, usually related to toxins created Jamaican vomiting disease and is recognized as weakening the aic fat oxidation in mice.

3.AMIODARONE

Amiodarone is an iodine containing benzofuran create highly effective in the treatment of cardiac arrhythmias. The use of this substance is often related to an increase in serum aminotransferase levels. Long-term therapy can cause fatty infiltration of the liver and form large vesicles of similar pathological changes in alcoholic hepatitis. Through examination under electron microscopy shows the lysosomes containing the form myelin lamellae due to the accumulation of phospholipid. Ideally, one should stop taking amiodarone when signs of liver damage; however, this is often not thuchien if amiodarone is the only drug control intractable arrhythmias are life threatening to the patient.

4.GLUCOCORTICOIDS

Glucocorticoid high doses can cause fatty liver. This effect occurs mostly in children. The main cause of fatty liver is caused by the increased liberation of fatty acids from adipose tissue. Fatty liver can recover when stopped glucocorticoid.

5.TAMOXIFEN

Tamoxifen is a nonsteroidal estrogen-resistant compound used primarily in the treatment of assistance in breast cancer. It competes with estrogen binding sites in the breast tissue and other tissues. Some causes an increase in enzyme aminotransferase and comes with fatty infiltration of the liver was noted on ultrasound and liver biopsy. Results of liver biopsy performed from May 7th to May 12th after starting treatment with tamoxifen found that the characteristics similar to the characteristics of pathological anatomy disease nonalcoholic steatohepatitis, which is quit lipid vesicles form large lobes and portal inflammation, and fibrosis Mallory bodies.